Following the launch of the “pro-aging“- inspired skincare brand FRAME® – www.framecosmetics.com – that seeks to offer a 360 degrees skin care and wellness ritual according to the teachings of the Mediterranean culture of wellness – VOS Group – www.vosgroup.it/en – reflected on the success of its creation and set its sights on a project that would ultimately bring dermocosmetics into a new, revolutionary realm of skin care science: the creation of mìsula®. The founding of the Frame brand had already established a step further in innovation within the sphere of skin care, in terms of philosophy, approach, science, and formulation and production of cosmetic products. In terms of philosophy, FRAME® shifted the discourse of “anti-aging” to a “pro-aging” approach to reflect the awareness that the way we perceive our age does actually influence the way we live. In terms of approach, FRAME® insisted on the fact that without internal wellness, external beauty is impossible to achieve, and thus it established a wellness-oriented skin care regimen based on: Cosmeceuticals, Nutraceuticals, Supplements, Vitamins, Herbal Extracts and Mechanobiological Devices. Now, building on years of collaboration with its Scientific Advisory Board (SAB) and leveraging on its own experience and expertise gained from over 30 years as a sector leader,  VOS Group has brought to life its most ambitious scientific and creative endeavor yet: mìsula®. This “sister” brand to FRAME® is essentially a condensed but highly specialized collection of skin care products that take dermocosmetics even farther. 
In creating some of the most targeted and effective anti-aging formulations on the market, mìsula® utilizes the most advanced technology currently available and leverages on insights gained from extensive research done in collaboration with leading Italian Universities and VOS Group’s R&D branch. Particular emphasis is put on the active ingredients that enrich the products in highly concentrated doses. The exclusive patented formulas and medicinal plant extracts from cultivated or spontaneous plant species – ingredients that are all local to the Mediterranean basin – are the foundation of the mìsula® dermocosmetics. Specifically, the raw materials that make mìsula®’s skincare so effective are cultivated in the protected Pollino National Park – which is a UNESCO-recognized “geopark” – in the region of Basilicata, in southern Italy. Our plant extracts are certified organic by the Italian Association for Organic Agriculture and are cultivated using integrated farming practices. Once the plants have been harvested from our cultivation site in the Pollino National Park, the extracts are obtained within four hours, never beyond that, in order to fully preserve the integrity of the active ingredients and their natural properties. Thanks to VOS Group’s extensive network of companies, mìsula® benefits from complete traceability. Its entire product chain is managed internally, from the cultivation of vegetable, plant, and herbal raw materials all the way to the marketing of the finished product. While FRAME® seeks to provide the essentials of an integrative skin care regimen, – complete with nutraceuticals and mechanobiological devices – mìsula® offers the most ambitious and ground breaking formulas that aim to support the skin’s own circadian rhythm, which manages its recovery, hydration levels and processes such as cell renewal. By understanding these rhythms and identifying when the skin will be under the most stress and when repair is needed, the products are more efficient at preventing premature aging and damage. Our skin cells operate to their own internal 24-hour clock, performing different functions at different times of the day to help your skin protect and repair itself from any potential harm. The main innovation of mìsula® consists of offering, at every moment of the day, its skincare. Our chronobiology-based formulations provides completely novel skin care experiences. Products that embrace the ideas of well-aging and “me time” in a range simply called CHRONOCEUTICALS… READ MORE
ABOUT CHRONOBIOLOGY & CIRCADIAN RHYTHMS The cyclical nature of time affects virtually all aspects of our being and is the basis of the underlying rhythmicity which is typical of our lives. To "tell time", most living organisms use internal timing mechanisms known as "biological clocks". These "clocks"coordinate our physiological and behavioral functions and interactions with our environment. One of the strongest influences on rhythmicity is the solar day...    LEARN MORE
ABOUT CHRONOBIOLOGY OF THE SKIN All life on earth and each organ in our body follows circadian rhythms that revolve around the 24-hour light/dark cycle. You are probably not aware that your skin follows its own circadian rhythm, but this cycle determines every action of your skin cells from the growth of new tissue to damage repair... LEARN MORE
ABOUT BARRIER FUNCTION RHYTHMS: The skin has its own chronobiological rhythms. It is even one of the first circadian rhythms to develop in children. At birth, children do not know a day lasts 24 hours, which explains why they do not sleep through the night, but their skin acquires its circadian variations very early, in particular as regards hydration... LEARN MORE
ABOUT SKIN ANTI-AGING STRATEGIES Skin aging is a complex biological process influenced by a combination of endogenous  (intrinsic) and exogenous (extrinsic) factors. Since skin health and beauty is considered one of the principal factors that represent overall “well-being” and the perception of “health” in humans, several anti-aging strategies have been developed during recent years... LEARN MORE
  ABOUT PHOTOPROTECTION & SYSTEMIC ANTIOXIDANTS Chronic photo-damage of the skin manifests itself as extrinsic skin aging (photo-aging). DNA photodamage and UV-generated reactive oxygen species (ROS) are the initial molecular events that lead to most of the typical histological and clinical manifestations of chronic photodamage of the skin... LEARN MORE
ABOUT DEREGULATION OF THE SKIN’S CIRCADIAN RHYTHM Stress, jetlag, shift working hours, intense lifestyles and even exposure to blue light emissions from the screens of ubiquitous electronic devices such as laptops, tablets and mobile phones, disrupt the body’s circadian clock, which leads to the deregulation of the skin’s circadian rhythm. As a consequence, the skin essentially becomes “lost in time," showing signs of fatigue and becoming more prone to external aggressors...

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  The world of natural skincare is constantly growing and changing. We are dedicated to providing our customers with only top-tier products, based on the most current scientific knowledge. Ours is a fresh approach to luxury skincare: when using Mediterranean botanical ingredients in their purest form leveraging the power of nature within the context of science and offering products that are not only good for your skin, but also good for our planet. From developing new products to developing new processes, innovation is central to how we work and grow on a daily basis. Our ambition is to become the most conscientious and influential natural skincare company in the world, and we can achieve this by expanding our knowledge in all aspects of skincare, educating and empowering consumers, inspiring and sharing our passion in others, being ethical, responsible, and principled in all aspects of our business.